Extreme Heat & Health Alerts (Italy/Europe): A record-breaking European heatwave is pushing Italy’s health system into crisis mode, with the Italian Ministry of Health placing 18 cities on Level 3 “red alert” (bollino rosso) and warnings that even healthy adults face immediate risk; across Europe, hospitals report surges in heat-related visits and equipment strain, while France and other countries impose alcohol bans and cancel mass events to protect patients. Climate Change Attribution: A rapid-attribution study says this June’s heat was made far more likely by human-caused warming, with temperatures running 5–12°C above seasonal averages across France, Germany, Italy, Spain and southern England—scientists warn “get used to it.” Cancer Care Update (EU/Italy): The EMA’s CHMP issued a positive opinion for Eli Lilly’s Jaypirca (pirtobrutinib) for adults with chronic lymphocytic leukemia across all lines, including for patients who haven’t had a BTK inhibitor. Real-World Oncology (Italy): Italian Lymphoma Foundation data on mogamulizumab (Poteligeo) in routine practice reports durable responses in mycosis fungoides and Sézary syndrome, with about half of previously treated patients achieving responses lasting at least 4 months. Disaster Response (Venezuela/EU): After twin earthquakes, the death toll in Venezuela has climbed to 920+ with tens of thousands missing; the EU has activated civil protection support, including Italy sending a medical team and Copernicus satellite mapping for relief.